Antibody response and leukemia development in mice inoculated neonatally with the Moloney virus.
نویسندگان
چکیده
Mice infected neonatally with homogenates from lymphomas induced by the Moloney virus showed a deficient or delayed antibody response, measured by the indirect fluorescent antibody test against Moloney lymphoma target cells in com parison with mice in.fected as adults. In neonatally infected mice there was a corre lation between the development of antibodies and the length of the preleukemic latency period.
منابع مشابه
Proviral activation of the c-myb proto-oncogene is detectable in preleukemic mice infected neonatally with Moloney murine leukemia virus but not in resulting end stage T lymphomas.
Moloney murine leukemia virus induces myeloid leukemia when inoculated intravenously into pristane-primed adult BALB/c mice. One hundred percent of these tumors show insertional activation of the c-myb proto-oncogene, and reverse transcriptase PCR assays have shown that the c-myb activation could be detected soon after infection. We tested BALB/c and NIH Swiss mice that had been inoculated as n...
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عنوان ژورنال:
- Cancer research
دوره 25 6 شماره
صفحات -
تاریخ انتشار 1965